The silent information regulator 2 (Sir2) family of proteins or also known as sirtuins was initially identified by studying on mating type regulation in yeast Saccharomyces cerevisiae [1]. Sirtuins are a family of enzymes and implicated in a variety of biological processes including DNA regulation, metabolism, longevity, cell survival, apoptosis, and stress resistance [2-4]. Basically, sirtuins are protein deacetylases that catalyze NAD+-dependent deacetylation reactions [2] and belong to the third family (Class III family) of histone deacetylase enzymes (HDACs). Moreover, members of the sirtuin family are highly conserved in catalytic core domain to catalyze deacetylation and clearly defined by their different intracellular. The class III HDACs contains seven sirtuin family members from Sirtuin-1 (SIRT1) to SIRT7 and all members are present in nearly all subcellular compartments including nucleus, cytoplasm and mitochondria [3]. SIRTs 1, 6 and 7 are reported as primary nuclear proteins [1, 5], SIRTs 3, 4 and 5 are sequentially conserved in other mitochondrial sirtuins and localized to mitochondria [5], while SIRT2 is predominantly cytoplasmic/cytosolic [1, 5-8].
References:
We provide a collection of data in database that we used in our research and we provide the link to NCBI Protein Database for each type of sequence based on their ACCESSION ID.
We also provide our data in CSV formats and it can be downloaded and used for further research. We also share our code in this section.